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Hypothalamus–pituitary–adrenal (HPA) Axis and HPA dysfunction

9/2/2025

2 Comments

 

by Rose Rohloff

Information collected from general, multiple AI common sources, unless otherwise denoted.

Perpetual Fight-or-Flight Stress

The HPA axis is a neuroendocrine system that is part of the body's fight-or-flight reaction in times of stress or emergency = Hypothalamus, the Pituitary and the Adrenal glands. 
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​HPA Axis Dysfunction leads to constant biofeedback of hormone release, constant stress in perpetual fight-or-flight state with Cortisol staying high → Metabolic disorders, Blood glucose staying high → Mental health issues → Immunity shut down (cancers) → Heart rate accelerates and Blood pressure increases → etc. 

Many people are not being diagnosed with this condition by MDs and are simply put on dangerous drugs (antidepressants/SSRIs/benzos) with issues not being addressed:
  1. Spiritual Health: align with God, pray, give praise and thanks to God, and use healing frequencies to calm.
  2. Spike proteins and nanotech targeting organs (read https://www.delphinehc.com/blog/what-exactly-are-in-the-shots)
  3. Heavy metal toxicity: we are being sprayed with glyphosate, chemtrails with mercury, aluminum, cadmium, etc. etc. DETOX heavy metal to eliminate neurotoxins. "The primary heavy metal neurotoxins for humans are lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), and aluminum (Al)." (This list is not all-inclusive.) 
  4. Micronutrient imbalances: Usually low but can be high (e.g. with Roundup chelating with copper in the soil, tattoos, etc.) Copper, Selenium, Iodine, Magnesium, and Manganese are examples and not being addressed by MDs. The perfect balance of the whole endocrine system is essential. When one hormone is messed with, it is a cascading effect.
  5. Virus or Parasite infections Link to read.
  6. Nitric Oxide (NO), glutamine/glutathione productions: 
  • NO regulates all of our essential body functions, including neurocommunication, heart, ovaries, etc ... "Nitric oxide (NO) plays a significant and multifaceted role in the endocrine system, influencing hormone secretion, endocrine axis function, and systemic homeostasis. It is produced in various endocrine tissues and acts as a key regulator in the hypothalamic–pituitary–gonadal and hypothalamic–pituitary–adrenal axes, mediating neuroendocrine function and influencing the secretion of hormones such as oxytocin, vasopressin, and luteinizing hormone-releasing hormone (LHRH).
  • Glutamine (symbol Gln or Q) is an α-amino acid that is used in the biosynthesis of proteins. Glutamine plays a significant role in the endocrine system, particularly in the regulation of hormone secretion and metabolism within pancreatic islets and intestinal enteroendocrine cells. 
  • Glutathione plays a critical role in maintaining the health and function of the endocrine system, primarily through its actions as the body's master antioxidant and a key facilitator of detoxification processes. The endocrine system, which regulates hormones that control metabolism, growth, reproduction, and mood, is highly susceptible to damage from oxidative stress and environmental toxins. Glutathione helps protect endocrine cells, which are among the most metabolically active and thus vulnerable to oxidative damage, by neutralizing free radicals and preventing cellular dysfunction and premature cell death."
This information is not all-inclusive and is meant as a high-level introduction regarding issues with an essential major system of the body. Many are possibly affected without diagnosis or resolution.
Individuals need to champion their own healthcare, know their systems, and push to be tested for any of the underlying conditions, working with healers to:
  • focus on spiritual health regardless of any issue;
  • do major detox of heavy metals, for example chlorella, milk thistle, celery, etc.;
  • support the immune system with natural antimicrobials, zinc+copper+ionophore, or anthelmintics;
  • rebalance micronutrients with healthy foods, and supplements;
  • make sure of proper balance of nitirc oxide, glutamine and glutathione. ​
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2 Comments
Heyward
9/6/2025 08:48:35 am

Amazing information Rose! But...WHAT DO I DO? What is my next step in assessing and treating HPA issues??

Reply
Rose Rohloff
9/6/2025 07:49:01 pm

Thank you Heyward. I added some options for individuals to investigate based upon what their bodies may be experiencing. Thank you for reading.

Reply



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  • DHC
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