Nitric oxide (NO) - why you should know about this most important gas, created in our bodies

by Rose Rohloff

Contribution by Dr John Marx, MB BS, BSc.(Hons)

Nitrate and Nitrite in Health and Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147587/

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Nitric Oxide (NO) was discovered through research in the 1970s-80s
Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad shared the Noble Prize in 1998 for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system

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Effects of Adding L-arginine orally to standard therapy in patients with Covid-19; Randomized, double-blind, placebo-controlled, parallel-group trial.  
Sept 09, 2021
Giuseppe Fiorentino 1 Antonietta Coppola 1 Raffaele Izzo Anna Annunziata Mariano Bernardo Angela Lombardi ​Show all authors

"Strikingly, patients treated with L-arginine exhibited a significantly reduced in-hospital stay vs placebo, with a median (interquartile range 25th,75th percentile) of 46 days (45,46) in the placebo group vs 25 days (21,26) in the L-arginine group (p < 0.0001); these findings were also confirmed after adjusting for potential confounders including age, duration of symptoms, comorbidities, D-dimer, as well as antiviral and anticoagulant treatments." Read full Lancet article

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Bioflex, maker of Photo Bio Modulation (PBM) "red light" therapies

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What does NO do?

• "Nitric oxide, having a free electron, is a free radical, making it an interesting signaling molecule. NO functions as a neurotransmitter, a macrophage-derived host-defense molecule, inhibits platelet aggregation and endothelium adhesion molecule expression, is an antioxidant, and is a potent vasodilator [1,2]. Nitric oxide is an endothelium-derived relaxing factor (EDRF)...Due to its many roles, loss of NO bioactivity contributes to disease in a variety of conditions including hemolytic anemias like sickle cell disease [8], transfusion of older blood [9], and endothelial dysfunction that occurs in pathological conditions like metabolic syndrome [10]" NIH article
• Affects major systems: platelets, ovaries, neuro, cardiac ... inflammatory response
• Issues with clotting, collagen, hypertension, fertility, etc. .... 

... Deep dives into NO are needed for an individual's  health - educate yourself,  and then discuss with clinicians. 

Nitric Oxide Signaling in Biology

Nitric Oxide signaling in biology.pdf
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How many drugs are prescribed when there are simple natural remedies available?

by Dr John Marx, MB BS, BSc.(Hons)

Are we only beginning to understand this amazing gas, and the miraculous function of the body?