Nitric oxide (NO) - why you should know about this most important gas, created in our bodies

by Rose Rohloff

Nitrate and Nitrite in Health and Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147587/

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Nitric Oxide (NO) was discovered through research in the 1970s-80s
Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad shared the Noble Prize in 1998 for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system

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Effects of Adding L-arginine orally to standard therapy in patients with Covid-19; Randomized, double-blind, placebo-controlled, parallel-group trial.  
Sept 09, 2021
Giuseppe Fiorentino 1 Antonietta Coppola 1 Raffaele Izzo Anna Annunziata Mariano Bernardo Angela Lombardi ​Show all authors

"Strikingly, patients treated with L-arginine exhibited a significantly reduced in-hospital stay vs placebo, with a median (interquartile range 25th,75th percentile) of 46 days (45,46) in the placebo group vs 25 days (21,26) in the L-arginine group (p < 0.0001); these findings were also confirmed after adjusting for potential confounders including age, duration of symptoms, comorbidities, D-dimer, as well as antiviral and anticoagulant treatments." Read full Lancet article

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Bioflex, maker of Photo Bio Modulation (PBM) "red light" therapies

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What does NO do?

• "Nitric oxide, having a free electron, is a free radical, making it an interesting signaling molecule. NO functions as a neurotransmitter, a macrophage-derived host-defense molecule, inhibits platelet aggregation and endothelium adhesion molecule expression, is an antioxidant, and is a potent vasodilator [1,2]. Nitric oxide is an endothelium-derived relaxing factor (EDRF)...Due to its many roles, loss of NO bioactivity contributes to disease in a variety of conditions including hemolytic anemias like sickle cell disease [8], transfusion of older blood [9], and endothelial dysfunction that occurs in pathological conditions like metabolic syndrome [10]" NIH article
• Affects major systems: platelets, ovaries, neuro, cardiac ... inflammatory response
• Issues with clotting, collagen, hypertension, fertility, etc. .... 

... Deep dives into NO are needed for an individual's  health - educate yourself,  and then discuss with clinicians. 

Nitric Oxide Signaling in Biology

Nitric Oxide signaling in biology.pdf
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Are we only beginning to understand this amazing gas, and the miraculous function of the body?